Authors
Ricardo Segurado, Sevilla D Detera-Wadleigh, Douglas F Levinson, Cathryn M Lewis, Michael Gill, John I Nurnberger, Nick Craddock, J Raymond DePaulo, Miron Baron, Elliot S Gershon, Jenny Ekholm, Sven Cichon, Gustavo Turecki, Stephan Claes, John R Kelsoe, Peter R Schofield, Renee F Badenhop, J Morissette, Hilary Coon, Douglas Blackwood, L Alison McInnes, Tatiana Foroud, Howard J Edenberg, Theodore Reich, John P Rice, Alison Goate, Melvin G McInnis, Francis J McMahon, Judith A Badner, Lynn R Goldin, Phil Bennett, Virginia L Willour, Peter P Zandi, Jianjun Liu, Conrad Gilliam, Suh-Hang Juo, Wade H Berrettini, Takeo Yoshikawa, Leena Peltonen, Jouko Lönnqvist, Markus M Nöthen, Johannes Schumacher, Christine Windemuth, Marcella Rietschel, Peter Propping, Wolfgang Maier, Martin Alda, Paul Grof, Guy A Rouleau, Jurgen Del-Favero, Christine Van Broeckhoven, Julien Mendlewicz, Rolf Adolfsson, M Anne Spence, Hermann Luebbert, Linda J Adams, Jennifer A Donald, Philip B Mitchell, Nicholas Barden, Eric Shink, William Byerley, Walter Muir, Peter M Visscher, Stuart Macgregor, Hugh Gurling, Gursharan Kalsi, Andrew McQuillin, Michael A Escamilla, Victor I Reus, Pedro Leon, Nelson B Freimer, Henrik Ewald, Torben A Kruse, Ole Mors, Uppala Radhakrishna, Jean-Louis Blouin, Stylianos E Antonarakis, Nurten Akarsu
Publication date
2003/7/1
Journal
The American Journal of Human Genetics
Volume
73
Issue
1
Pages
49-62
Publisher
Elsevier
Description
Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an effort to identify regions with significant support for linkage in the combined data. The two primary analyses considered available linkage data for "very narrow" (i.e., BP-I and schizoaffective disorder–BP) and "narrow" (i.e., adding BP-II disorder) disease models, with the ranks weighted for sample size. A "broad" model (i.e., adding recurrent major depression) and unweighted analyses were also performed. No region achieved genomewide statistical significance by several simulation-based criteria. The most significant P values (<.01) were observed on chromosomes 9p22.3-21.1 (very narrow), 10q11.21-22.1 (very narrow), and 14q24.1-32.12 (narrow). Nominally significant P values were observed in adjacent …
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R Segurado, SD Detera-Wadleigh, DF Levinson… - The American Journal of Human Genetics, 2003