Authors
Farzaneh Rahmani, Matthew R Brier, Brian A Gordon, Nicole McKay, Shaney Flores, Sarah Keefe, Russ Hornbeck, Beau Ances, Nelly Joseph‐Mathurin, Chengjie Xiong, Guoqiao Wang, Cyrus A Raji, Jorge J Libre‐Guerra, Richard J Perrin, Eric McDade, Alisha Daniels, Celeste Karch, Gregory S Day, Adam M Brickman, Michael Fulham, Clifford R Jack Jr, Christian la La Fougère, Gerald Reischl, Peter R Schofield, Hwamee Oh, Johannes Levin, Jonathan Vöglein, David M Cash, Igor Yakushev, Takeshi Ikeuchi, William E Klunk, John C Morris, Randall J Bateman, Tammie LS Benzinger, Dominantly Inherited Alzheimer Network (DIAN)
Publication date
2023/12/15
Journal
Human Brain Mapping
Volume
44
Issue
18
Pages
6375-6387
Publisher
John Wiley & Sons, Inc.
Description
Carriers of mutations responsible for dominantly inherited Alzheimer disease provide a unique opportunity to study potential imaging biomarkers. Biomarkers based on routinely acquired clinical MR images, could supplement the extant invasive or logistically challenging) biomarker studies. We used 1104 longitudinal MR, 324 amyloid beta, and 87 tau positron emission tomography imaging sessions from 525 participants enrolled in the Dominantly Inherited Alzheimer Network Observational Study to extract novel imaging metrics representing the mean (μ) and standard deviation (σ) of standardized image intensities of T1‐weighted and Fluid attenuated inversion recovery (FLAIR) MR scans. There was an exponential decrease in FLAIR‐μ in mutation carriers and an increase in FLAIR and T1 signal heterogeneity (T1‐σ and FLAIR‐σ) as participants approached the symptom onset in both supramarginal, the right …
Total citations
20241
Scholar articles
F Rahmani, MR Brier, BA Gordon, N McKay, S Flores… - Human Brain Mapping, 2023