Authors
DP Hibar, Lars Tjelta Westlye, Nhat Trung Doan, Neda Jahanshad, JW Cheung, Christopher RK Ching, Amelia Versace, AC Bilderbeck, Anne Uhlmann, B Mwangi, B Krämer, B Overs, Cecilie Bhandari Hartberg, Christoph Abé, Danai Dima, Dominik Grotegerd, Emma Sprooten, Erlend Bøen, Enrique Jimenez, Fleur M Howells, G Delvecchio, H Temmingh, J Starke, JRC Almeida, JM Goikolea, J Houenou, Lauren M Beard, L Rauer, Lucija Abramovic, M Bonnin, MF Ponteduro, M Keil, MM Rive, N Yao, N Yalin, P Najt, PG Rosa, Ronny Redlich, S Trost, Saskia Hagenaars, SC Fears, S Alonso-Lana, TGM Van Erp, Thomas Nickson, TM Chaim-Avancini, TB Meier, Torbjørn Elvsåshagen, UK Haukvik, WH Lee, AH Schene, AJ Lloyd, AH Young, A Nugent, AM Dale, Andrea Pfennig, AM McIntosh, Beny Lafer, BT Baune, CJ Ekman, CA Zarate, CE Bearden, C Henry, Christian Simhandl, C McDonald, C Bourne, DJ Stein, DH Wolf, DM Cannon, DC Glahn, DJ Veltman, E Pomarol-Clotet, E Vieta, EJ Canales-Rodriguez, FG Nery, FLS Duran, GF Busatto, G Roberts, GD Pearlson, GM Goodwin, H Kugel, HC Whalley, HG Ruhe, JC Soares, JM Fullerton, JK Rybakowski, Jonathan Savitz, KT Chaim, Mar Fatjó-Vilas, MG Soeiro-de-Souza, MP Boks, MV Zanetti, MCG Otaduy, MS Schaufelberger, Martin Alda, Martin Ingvar, ML Phillips, MJ Kempton, M Bauer, M Landén, NS Lawrence, NEM Van Haren, NR Horn, NB Freimer, Oliver Gruber, PR Schofield, PB Mitchell, RS Kahn, R Lenroot, R Machado-Vieira, RA Ophoff, S Sarró, Sophia Frangou, TD Satterthwaite, Tomas Hajek, Udo Dannlowski, Ulrik Fredrik Malt, Volker Arolt, WF Gattaz, WC Drevets, Xavier Caseras, Ingrid Agartz, PM Thompson, Ole Andreas Andreassen
Publication date
2018/4
Journal
Molecular psychiatry
Volume
23
Issue
4
Pages
932-942
Publisher
Nature Publishing Group
Description
Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies have been inconsistent. To address this, we performed the largest study to date of cortical gray matter thickness and surface area measures from brain magnetic resonance imaging scans of 6503 individuals including 1837 unrelated adults with BD and 2582 unrelated healthy controls for group differences while also examining the effects of commonly prescribed medications, age of illness onset, history of psychosis, mood state, age and sex differences on cortical regions. In BD, cortical gray matter was thinner in frontal, temporal and parietal regions of both brain hemispheres. BD had the strongest effects on left pars opercularis (Cohen’s d=− 0.293; P= 1.71× 10− 21), left fusiform gyrus (d=− 0.288; P= 8.25× 10− 21 …
Scholar articles
DP Hibar, LT Westlye, NT Doan, N Jahanshad… - Molecular psychiatry, 2018