Authors
Toni-Kim Clarke, Mark J Adams, Gail Davies, David M Howard, Lynsey S Hall, Sandosh Padmanabhan, Alison D Murray, Blair H Smith, Archie Campbell, Caroline Hayward, David J Porteous, Ian J Deary, Andrew M McIntosh
Publication date
2017/10
Journal
Molecular psychiatry
Volume
22
Issue
10
Pages
1376-1384
Publisher
Nature Publishing Group
Description
Alcohol consumption has been linked to over 200 diseases and is responsible for over 5% of the global disease burden. Well-known genetic variants in alcohol metabolizing genes, for example, ALDH2 and ADH1B, are strongly associated with alcohol consumption but have limited impact in European populations where they are found at low frequency. We performed a genome-wide association study (GWAS) of self-reported alcohol consumption in 112 117 individuals in the UK Biobank (UKB) sample of white British individuals. We report significant genome-wide associations at 14 loci. These include single-nucleotide polymorphisms (SNPs) in alcohol metabolizing genes (ADH1B/ADH1C/ADH5) and two loci in KLB, a gene recently associated with alcohol consumption. We also identify SNPs at novel loci including GCKR, CADM2 and FAM69C. Gene-based analyses found significant associations with genes …
Scholar articles
TK Clarke, MJ Adams, G Davies, DM Howard, LS Hall… - Molecular psychiatry, 2017