Authors
Horia C Stanescu, Mauricio Arcos-Burgos, Alan Medlar, Detlef Bockenhauer, Anna Kottgen, Liviu Dragomirescu, Catalin Voinescu, Naina Patel, Kerra Pearce, Mike Hubank, Henry AF Stephens, Valerie Laundy, Sandosh Padmanabhan, Anna Zawadzka, Julia M Hofstra, Marieke JH Coenen, Martin Den Heijer, Lambertus ALM Kiemeney, Delphine Bacq-Daian, Benedicte Stengel, Stephen H Powis, Paul Brenchley, John Feehally, Andrew J Rees, Hanna Debiec, Jack FM Wetzels, Pierre Ronco, Peter W Mathieson, Robert Kleta
Publication date
2011/2/17
Journal
New England Journal of Medicine
Volume
364
Issue
7
Pages
616-626
Publisher
Massachusetts Medical Society
Description
Background
Idiopathic membranous nephropathy is a major cause of the nephrotic syndrome in adults, but its etiologic basis is not fully understood. We investigated the genetic basis of biopsy-proven cases of idiopathic membranous nephropathy in a white population.
Methods
We performed independent genomewide association studies of single-nucleotide polymorphisms (SNPs) in patients with idiopathic membranous nephropathy from three populations of white ancestry (75 French, 146 Dutch, and 335 British patients). The patients were compared with racially matched control subjects; population stratification and quality controls were carried out according to standard criteria. Associations were calculated by means of a chi-square basic allele test; the threshold for significance was adjusted for multiple comparisons (with the Bonferroni method).
Results
In a joint analysis of data from the 556 patients studied …
Total citations
Scholar articles
HC Stanescu, M Arcos-Burgos, A Medlar… - New England Journal of Medicine, 2011