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Highly selective cation or anion sensing is imperative for many areas of technology, including environmental, biological, clinical, and waste management applications.[1] For heavy-and transition-metal ions (eg Pb2+, Cd2+, and Hg2+; Cu2+ and Fe3+), selective sensory protocols are particularly critical owing to their high toxicity and crucial role in biological systems.[2] Although various concepts in metal-ion sensing have been installed to enhance sensitivity, selectivity, and the dynamic working range,[3] the recognition of congregations of chemical species [4] and of multianalyte mixtures still poses a major challenge.[5] In this context, a “lab on a molecule” for the simultaneous, although only qualitative, detection of Zn2+, H+, and Na+ by a logic-gate approach has recently been described.[4] However, even this innovative approach follows the paradigm that is still dominating traditional sensor design: one receptor …