Authors
Mayank Goyal, Andrew M Demchuk, Bijoy K Menon, Muneer Eesa, Jeremy L Rempel, John Thornton, Daniel Roy, Tudor G Jovin, Robert A Willinsky, Biggya L Sapkota, Dar Dowlatshahi, Donald F Frei, Noreen R Kamal, Walter J Montanera, Alexandre Y Poppe, Karla J Ryckborst, Frank L Silver, Ashfaq Shuaib, Donatella Tampieri, David Williams, Oh Young Bang, Blaise W Baxter, Paul A Burns, Hana Choe, Ji-Hoe Heo, Christine A Holmstedt, Brian Jankowitz, Michael Kelly, Guillermo Linares, Jennifer L Mandzia, Jai Shankar, Sung-Il Sohn, Richard H Swartz, Philip A Barber, Shelagh B Coutts, Eric E Smith, William F Morrish, Alain Weill, Suresh Subramaniam, Alim P Mitha, John H Wong, Mark W Lowerison, Tolulope T Sajobi, Michael D Hill
Publication date
2015/3/12
Journal
New England Journal of Medicine
Volume
372
Issue
11
Pages
1019-1030
Publisher
Massachusetts Medical Society
Description
Background
Among patients with a proximal vessel occlusion in the anterior circulation, 60 to 80% of patients die within 90 days after stroke onset or do not regain functional independence despite alteplase treatment. We evaluated rapid endovascular treatment in addition to standard care in patients with acute ischemic stroke with a small infarct core, a proximal intracranial arterial occlusion, and moderate-to-good collateral circulation.
Methods
We randomly assigned participants to receive standard care (control group) or standard care plus endovascular treatment with the use of available thrombectomy devices (intervention group). Patients with a proximal intracranial occlusion in the anterior circulation were included up to 12 hours after symptom onset. Patients with a large infarct core or poor collateral circulation on computed tomography (CT) and CT angiography were excluded. Workflow times were measured …
Scholar articles
M Goyal, AM Demchuk, BK Menon, M Eesa, JL Rempel… - New England Journal of Medicine, 2015