Authors
Melanie D Sweeney, Axel Montagne, Abhay P Sagare, Daniel A Nation, Lon S Schneider, Helena C Chui, Michael G Harrington, Judy Pa, Meng Law, Danny JJ Wang, Russell E Jacobs, Fergus N Doubal, Joel Ramirez, Sandra E Black, Maiken Nedergaard, Helene Benveniste, Martin Dichgans, Costantino Iadecola, Seth Love, Philip M Bath, Hugh S Markus, Rustam A Salman, Stuart M Allan, Terence J Quinn, Rajesh N Kalaria, David J Werring, Roxana O Carare, Rhian M Touyz, Steve CR Williams, Michael A Moskowitz, Zvonimir S Katusic, Sarah E Lutz, Orly Lazarov, Richard D Minshall, Jalees Rehman, Thomas P Davis, Cheryl L Wellington, Hector M González, Chun Yuan, Samuel N Lockhart, Timothy M Hughes, Christopher LH Chen, Perminder Sachdev, John T O'Brien, Ingmar Skoog, Leonardo Pantoni, Deborah R Gustafson, Geert Jan Biessels, Anders Wallin, Eric E Smith, Vincent Mok, Adrian Wong, Peter Passmore, Frederick Barkof, Majon Muller, Monique MB Breteler, Gustavo C Román, Edith Hamel, Sudha Seshadri, Rebecca F Gottesman, Mark A van Buchem, Zoe Arvanitakis, Julie A Schneider, Lester R Drewes, Vladimir Hachinski, Caleb E Finch, Arthur W Toga, Joanna M Wardlaw, Berislav V Zlokovic
Publication date
2019/1/1
Journal
Alzheimer's & Dementia
Volume
15
Issue
1
Pages
158-167
Publisher
No longer published by Elsevier
Description
Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous disease with multiple contributors to its pathophysiology, including vascular dysfunction. The recently updated AD Research Framework put forth by the National Institute on Aging–Alzheimer's Association describes a biomarker-based pathologic definition of AD focused on amyloid, tau, and neuronal injury. In response to this article, here we first discussed evidence that vascular dysfunction is an important early event in AD pathophysiology. Next, we examined various imaging sequences that could be easily implemented to evaluate different types of vascular dysfunction associated with, and/or contributing to, AD pathophysiology, including changes in blood-brain barrier integrity and cerebral blood flow. Vascular imaging biomarkers of small vessel disease of the brain, which is responsible for >50% of dementia …
Scholar articles
MD Sweeney, A Montagne, AP Sagare, DA Nation… - Alzheimer's & Dementia, 2019