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Resource optimization in 5G Radio Access Networks (5G-RAN) has to face the dynamics over time in networks with increasing numbers of nodes and virtual network functions. In this context, multiple objectives need to be jointly optimized, and key application requirements such as latency must be enforced. In addition, virtual network functions realizing baseband processing are subject to failures of the cloud infrastructure, requiring an additional level of reliability. Overall, this is a complex problem to solve, requiring fast algorithms to cope with dynamic networks while avoiding resource overprovisioning. This paper considers the problem of optimal virtual function placement in 5G-RAN with reliability against a single DU Hotel failure and proposes a solution that takes service dynamics into account. Firstly, the joint optimization of the total number of DU Hotels, of the RU–DU latency and of the backup DU sharing in a …