Authors
Nuno Rodrigues Faria, Moritz UG Kraemer, Sarah C Hill, Jaqueline Góes de Jesus, RS de Aguiar, Felipe CM Iani, Joilson Xavier, Josh Quick, Louis du Plessis, Simon Dellicour, Julien Thézé, RDO Carvalho, Guy Baele, C-H Wu, Paola P Silveira, MB Arruda, MA Pereira, G d C Pereira, José Lourenço, Uri Obolski, L Abade, TI Vasylyeva, M Giovanetti, D Yi, DJ Weiss, GRW Wint, FM Shearer, Shelby Funk, B Nikolay, V Fonseca, TER Adelino, MAA Oliveira, MVF Silva, L Sacchetto, PO Figueiredo, IM Rezende, EM Mello, RFC Said, DA Santos, ML Ferraz, MG Brito, LF Santana, MT Menezes, RM Brindeiro, A Tanuri, FCP Dos Santos, Margarida S Cunha, JS Nogueira, IM Rocco, AC Da Costa, SCV Komninakis, V Azevedo, AO Chieppe, ESM Araujo, MCL Mendonça, CC Dos Santos, CD Dos Santos, AM Mares-Guia, RMR Nogueira, PC Sequeira, RG Abreu, MHO Garcia, AL Abreu, O Okumoto, Erna Geessien Kroon, CFC De Albuquerque, K Lewandowski, ST Pullan, Miles Carroll, T De Oliveira, EC Sabino, RP Souza, Marc A Suchard, Philippe Lemey, GS Trindade, BP Drumond, AMB Filippis, NJ Loman, Simon Cauchemez, LCJ Alcantara, Oliver George Pybus
Publication date
2018/8/31
Journal
Science
Volume
361
Issue
6405
Pages
894-899
Publisher
American Association for the Advancement of Science
Description
The yellow fever virus (YFV) epidemic in Brazil is the largest in decades. The recent discovery of YFV in Brazilian Aedes species mosquitos highlights a need to monitor the risk of reestablishment of urban YFV transmission in the Americas. We use a suite of epidemiological, spatial, and genomic approaches to characterize YFV transmission. We show that the age and sex distribution of human cases is characteristic of sylvatic transmission. Analysis of YFV cases combined with genomes generated locally reveals an early phase of sylvatic YFV transmission and spatial expansion toward previously YFV-free areas, followed by a rise in viral spillover to humans in late 2016. Our results establish a framework for monitoring YFV transmission in real time that will contribute to a global strategy to eliminate future YFV epidemics.
Scholar articles
NR Faria, MUG Kraemer, SC Hill, J Góes de Jesus… - Science, 2018