Authors
David B Blossom, Alexander J Kallen, Priti R Patel, Alexis Elward, Luke Robinson, Ganpan Gao, Robert Langer, Kiran M Perkins, Jennifer L Jaeger, Katie M Kurkjian, Marilyn Jones, Sarah F Schillie, Nadine Shehab, Daniel Ketterer, Ganesh Venkataraman, Takashi Kei Kishimoto, Zachary Shriver, Ann W McMahon, K Frank Austen, Steven Kozlowski, Arjun Srinivasan, George Turabelidze, Carolyn V Gould, Matthew J Arduino, Ram Sasisekharan
Publication date
2008/12/18
Journal
New England Journal of Medicine
Volume
359
Issue
25
Pages
2674-2684
Publisher
Massachusetts Medical Society
Description
Background
In January 2008, the Centers for Disease Control and Prevention began a nationwide investigation of severe adverse reactions that were first detected in a single hemodialysis facility. Preliminary findings suggested that heparin was a possible cause of the reactions.
Methods
Information on clinical manifestations and on exposure was collected for patients who had signs and symptoms that were consistent with an allergic-type reaction after November 1, 2007. Twenty-one dialysis facilities that reported reactions and 23 facilities that reported no reactions were included in a case–control study to identify facility-level risk factors. Unopened heparin vials from facilities that reported reactions were tested for contaminants.
Results
A total of 152 adverse reactions associated with heparin were identified in 113 patients from 13 states from November 19, 2007, through January 31, 2008. The use of heparin …
Total citations
Scholar articles
DB Blossom, AJ Kallen, PR Patel, A Elward… - New England Journal of Medicine, 2008