Authors
Louis J Picker, Takashi K Kishimoto, C Wayne Smith, R Aaron Warnock, Eugene C Butcher
Publication date
1991/2/28
Journal
Nature
Volume
349
Issue
6312
Pages
796-799
Publisher
Nature Publishing Group UK
Description
ENDOTHELIAL cell leukocyte adhesion molecule-1 (ELAM-1) has been described as an inducible endothelial cell-adhesion molecule for neutrophils, and is believed to have a key role in the extravasation of these cells at sites of acute inflammation1–3. Here we report that ELAM-1-transfected COS cells also bind a unique skin-associated subset of circulating memory T cells defined by the expression of the cutaneous lymphocyte-associated antigen4,5. T cells expressing this antigen bind at least as well as neutrophils to expressed ELAM-1, whereas other lymphocytes in the peripheral blood bind poorly, or not at all. Immunohistological survey of chronically inflamed tissue specimens revealed that vascular expression of ELAM-1 occurs at cutaneous sites in preference to noncutaneous sites. We conclude that at sites of chronic inflammation, ELAM-1 may function as a skin vascular addressin, a tissue-selective …
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LJ Picker, TK Kishimoto, CW Smith, RA Warnock… - Nature, 1991