Authors
Takashi Kei Kishimoto, Mark A Jutila, Ellen Lakey Berg, Eugene C Butcher
Publication date
1989/9/15
Journal
Science
Volume
245
Issue
4923
Pages
1238-1241
Publisher
American Association for the Advancement of Science
Description
The neutrophil Mac-1 and gp100MEL-14 adhesion proteins are involved in neutrophil extravasation during inflammation. Both the expression and activity of Mac-1 are greatly increased after neutrophil activation. In contrast, neutrophils shed gp100MEL-14 from the cell surface within 4 minutes after activation with chemotactic factors or phorbol esters, releasing a 96-kilodalton fragment of the antigen into the supernatant. Immunohistology showed that gp100MEL-14 was downregulated on neutrophils that had extravasated into inflamed tissue. The gp100MEL-14 adhesion protein may participate in the binding of unactivated neutrophils to the endothelium; rapid shedding of gp100MEL-14 may prevent extravasation into and damage of normal tissues by activated neutrophils.
Total citations
Scholar articles
TK Kishimoto, MA Jutila, EL Berg, EC Butcher - Science, 1989