Authors
Rebeka Fejes, Nina Pilat, Martin Lutnik, Stefan Weisshaar, Anna M Weijler, Karsten Krüger, Agnes Draxler, Laura Bragagna, Jonathan M Peake, Richard J Woodman, Kevin D Croft, Catherine P Bondonno, Jonathan M Hodgson, Karl-Heinz Wagner, Michael Wolzt, Oliver Neubauer
Publication date
2024/7/5
Journal
Free Radical Biology and Medicine
Publisher
Pergamon
Description
Background
Vascular oxidative stress and low-grade inflammation are important in the pathology of cardiovascular disorders, including hypertension. Cell culture and animal studies suggest that inorganic dietary nitrate may attenuate oxidative stress and inflammation through nitric oxide (NO), and there is a need to investigate whether this translates to humans.
Aim
In this randomised, placebo-controlled crossover study, by measuring a combination of multiple blood biomarkers, we evaluated whether previously reported benefits of dietary nitrate translate to a reduced oxidative stress and an improved inflammation status in 15 men and women (age range: 56–71 years) with treated hypertension.
Methods
We investigated the effects of a single ∼400 mg-dose of nitrate at 3 hours post-ingestion (3H POST) and the daily consumption of 2×∼400 mg of nitrate over 4 weeks (4WK POST), through nitrate-rich versus nitrate …
Scholar articles
R Fejes, N Pilat, M Lutnik, S Weisshaar, AM Weijler… - Free Radical Biology and Medicine, 2024