Authors
Michael Fenech, Siegfried Knasmueller, Lisbeth E Knudsen, Micheline Kirsch-Volders, Permal Deo, Bernhard Franzke, Helga Stopper, Maria-Grazia Andreassi, Claudia Bolognesi, Varinderpal S Dhillon, Blanca Laffon, Karl-Heinz Wagner, Stefano Bonassi
Publication date
2021/7/1
Source
Mutation Research/Reviews in Mutation Research
Volume
788
Pages
108384
Publisher
Elsevier
Description
The purpose of the “Micronuclei and Disease” special issue (SI) is to: (i) Determine the level of evidence for association of micronuclei (MN), a biomarker of numerical and structural chromosomal aberrations, with risk of specific diseases in humans; (ii) Define plausible mechanisms that explain association of MN with each disease; (iii) Identify knowledge gaps and research needed to translate MN assays into clinical practice.
The “MN and Disease” SI includes 14 papers. The first is a review of mechanisms of MN formation and their consequences in humans. 11 papers are systematic reviews and/or meta-analyses of the association of MN with reproduction, child health, inflammation, auto-immune disease, glycation, metabolic diseases, chronic kidney disease, cardiovascular disease, eleven common cancers, ageing and frailty. The penultimate paper focuses on effect of interventions on MN frequency in the elderly …
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Scholar articles
M Fenech, S Knasmueller, LE Knudsen… - Mutation Research/Reviews in Mutation Research, 2021