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Since ancient times, plants have been an exemplary source of medicine. Tobacco is an agricultural product processed from the leaves of plants in the genus Nicotiana. In Indian agriculture, tobacco has a prominent place. Tobacco could be developed as an important food crop in combination with its traditional use for smoking and chewing. Tobacco plants are also used in plant bioengineering, and some of the more than 70 species are grown as ornamentals. The chemistry of tobacco is unique with the presence of a wide spectrum of chemical compounds of which nicotine, solanesol, malic and citric acid were identified as potential chemicals which could be recovered and converted to value-added products. The alkaloid nicotine is popularly considered the most characteristic constituent of tobacco but nicotine is not highly addictive on its own. In consumption it most commonly appears in the forms of smoking, chewing, snuffing, or dipping tobacco. Because of the powerfully addictive properties of tobacco, tolerance and dependence develop. This situation necessitated to examine the green tobacco crop as a source for recovery of phytochemicals alone. With the objective of maximizing bio-mass production for optimum recovery of proteins, nicotine, solanesol and organic acids from green tobacco. Nicotine for treatment of Alzheimer disease, Parkinson disease, depression and anxiety, schizophrenia, attention deficit hyperactivity disorder (ADHD), pain, and obesity.