Authors
Edward Chow, Yvette M van der Linden, Daniel Roos, William F Hartsell, Peter Hoskin, Jackson SY Wu, Michael D Brundage, Abdenour Nabid, Caroline JA Tissing-Tan, Bing Oei, Scott Babington, William F Demas, Carolyn F Wilson, Ralph M Meyer, Bingshu E Chen, Rebecca KS Wong
Publication date
2014/2/1
Journal
The Lancet Oncology
Volume
15
Issue
2
Pages
164-171
Publisher
Elsevier
Description
Background
Although repeat radiation treatment has been shown to palliate pain in patients with bone metastases from multiple primary origin sites, data for the best possible dose fractionation schedules are lacking. We aimed to assess two dose fractionation schedules in patients with painful bone metastases needing repeat radiation therapy.
Methods
We did a multicentre, non-blinded, randomised, controlled trial in nine countries worldwide. We enrolled patients 18 years or older who had radiologically confirmed, painful (ie, pain measured as ≥2 points using the Brief Pain Inventory) bone metastases, had received previous radiation therapy, and were taking a stable dose and schedule of pain-relieving drugs (if prescribed). Patients were randomly assigned (1:1) to receive either 8 Gy in a single fraction or 20 Gy in multiple fractions by a central computer-generated allocation sequence using dynamic minimisation …
Total citations
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