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Owing to a growing desire to reduce energy consumption and widely anticipated hurdles to the continued technology scaling promised by Moore's law, techniques and technologies such as inexact circuits and probabilistic CMOS (PCMOS) have gained prominence. These radical approaches trade accuracy at the hardware level for significant gains in energy consumption, area, and speed. While holding great promise, their ability to influence the broader milieu of computing is limited due to two shortcomings. First, they were mostly based on ad-hoc hand designs and did not consider algorithmically well-characterized automated design methodologies. Also, existing design approaches were limited to particular layers of abstraction such as physical, architectural and algorithmic or more broadly software. However, it is well-known that significant gains can be achieved by optimizing across the layers. To respond to …