Authors
Mayank Goyal, Bijoy K Menon, Wim H Van Zwam, Diederik WJ Dippel, Peter J Mitchell, Andrew M Demchuk, Antoni Dávalos, Charles BLM Majoie, Aad van Der Lugt, Maria A De Miquel, Geoffrey A Donnan, Yvo BWEM Roos, Alain Bonafe, Reza Jahan, Hans-Christoph Diener, Lucie A Van Den Berg, Elad I Levy, Olvert A Berkhemer, Vitor M Pereira, Jeremy Rempel, Mònica Millán, Stephen M Davis, Daniel Roy, John Thornton, Luis San Román, Marc Ribó, Debbie Beumer, Bruce Stouch, Scott Brown, Bruce CV Campbell, Robert J Van Oostenbrugge, Jeffrey L Saver, Michael D Hill, Tudor G Jovin
Publication date
2016/4/23
Journal
The Lancet
Volume
387
Issue
10029
Pages
1723-1731
Publisher
Elsevier
Description
Background
In 2015, five randomised trials showed efficacy of endovascular thrombectomy over standard medical care in patients with acute ischaemic stroke caused by occlusion of arteries of the proximal anterior circulation. In this meta-analysis we, the trial investigators, aimed to pool individual patient data from these trials to address remaining questions about whether the therapy is efficacious across the diverse populations included.
Methods
We formed the HERMES collaboration to pool patient-level data from five trials (MR CLEAN, ESCAPE, REVASCAT, SWIFT PRIME, and EXTEND IA) done between December, 2010, and December, 2014. In these trials, patients with acute ischaemic stroke caused by occlusion of the proximal anterior artery circulation were randomly assigned to receive either endovascular thrombectomy within 12 h of symptom onset or standard care (control), with a primary outcome of …
Scholar articles
M Goyal, BK Menon, WH Van Zwam, DWJ Dippel… - The Lancet, 2016
M Goyal, BK Menon, WH van Zwam, DW Dippel… - Lancet, 2016