Authors
Joseph P Broderick, Yuko Y Palesch, Andrew M Demchuk, Sharon D Yeatts, Pooja Khatri, Michael D Hill, Edward C Jauch, Tudor G Jovin, Bernard Yan, Frank L Silver, Rüdiger Von Kummer, Carlos A Molina, Bart M Demaerschalk, Ronald Budzik, Wayne M Clark, Osama O Zaidat, Tim W Malisch, Mayank Goyal, Wouter J Schonewille, Mikael Mazighi, Stefan T Engelter, Craig Anderson, Judith Spilker, Janice Carrozzella, Karla J Ryckborst, L Scott Janis, Renée H Martin, Lydia D Foster, Thomas A Tomsick
Publication date
2013/3/7
Journal
New England Journal of Medicine
Volume
368
Issue
10
Pages
893-903
Publisher
Massachusetts Medical Society
Description
Background
Endovascular therapy is increasingly used after the administration of intravenous tissue plasminogen activator (t-PA) for patients with moderate-to-severe acute ischemic stroke, but whether a combined approach is more effective than intravenous t-PA alone is uncertain.
Methods
We randomly assigned eligible patients who had received intravenous t-PA within 3 hours after symptom onset to receive additional endovascular therapy or intravenous t-PA alone, in a 2:1 ratio. The primary outcome measure was a modified Rankin scale score of 2 or less (indicating functional independence) at 90 days (scores range from 0 to 6, with higher scores indicating greater disability).
Results
The study was stopped early because of futility after 656 participants had undergone randomization (434 patients to endovascular therapy and 222 to intravenous t-PA alone). The proportion of participants with a modified …
Total citations
Scholar articles
JP Broderick, YY Palesch, AM Demchuk, SD Yeatts… - New England Journal of Medicine, 2013