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The inflammatory response in allergic asthma is dominated by a CD4+ T helper 2 (Th2) cell signature and amplified in self-enforcing loops, leaving the host unable to terminate the immune reaction and leading to distress in patients. Deregulated expression of microRNAs (miRNAs) has been associated with various disease conditions, including asthma. Whether miRNAs stabilize the Th2 population in the allergic inflamed lung is not well understood and raise the need for deeper analysis. Using well established mouse models of ovalbumin-induced chronic airway inflammation in combination with FACS-sorting, distinct Th2 cells were isolated from chronic inflamed lung tissue and subjected to microarray analyses (mRNA and microRNA). Naïve T cells from sham immunized and sham treated mice were used as a control population. A multi-omics network approach, Integration of Differential …