Authors
Lorenzo Galluzzi, Stuart A Aaronson, John Abrams, Emad S Alnemri, David W Andrews, Eric H Baehrecke, Nicolas G Bazan, Mikhail V Blagosklonny, Klas Blomgren, Christopher Borner, Dale E Bredesen, Catherine Brenner, Maria Castedo, John A Cidlowski, Aaron Ciechanover, Gerry M Cohen, Vincenzo De Laurenzi, Ruggero De Maria, Mohanish Deshmukh, Brian D Dynlacht, Wafik S El-Deiry, Richard A Flavell, Simone Fulda, Carmen Garrido, Pierre Golstein, Marie-Lise Gougeon, Douglas R Green, Hinrich Gronemeyer, György Hajnóczky, J Marie Hardwick, Michael O Hengartner, Hidenori Ichijo, Marja Jäättelä, Olivier Kepp, Adi Kimchi, Daniel J Klionsky, Richard A Knight, Sally Kornbluth, Sharad Kumar, Beth Levine, Stuart A Lipton, Enrico Lugli, Frank Madeo, W Malorni, J-CW Marine, Seamus J Martin, Jan Paul Medema, Patrick Mehlen, Gerry Melino, Ute M Moll, Eugenia Morselli, Shigekazu Nagata, Donald W Nicholson, Pierluigi Nicotera, Gabriel Nuñez, Moshe Oren, Josef Penninger, Shazib Pervaiz, Marcus E Peter, Mauro Piacentini, Jochen HM Prehn, Hamsa Puthalakath, Gabriel A Rabinovich, Rosario Rizzuto, Cecilia MP Rodrigues, David C Rubinsztein, Thomas Rudel, Luca Scorrano, Hans-Uwe Simon, Hermann Steller, Jürg Tschopp, Yoshihide Tsujimoto, Peter Vandenabeele, Ilio Vitale, Karen H Vousden, Richard J Youle, Junying Yuan, Boris Zhivotovsky, Guido Kroemer
Publication date
2009/8
Source
Cell Death & Differentiation
Volume
16
Issue
8
Pages
1093-1107
Publisher
Nature Publishing Group
Description
Cell death is essential for a plethora of physiological processes, and its deregulation characterizes numerous human diseases. Thus, the in-depth investigation of cell death and its mechanisms constitutes a formidable challenge for fundamental and applied biomedical research, and has tremendous implications for the development of novel therapeutic strategies. It is, therefore, of utmost importance to standardize the experimental procedures that identify dying and dead cells in cell cultures and/or in tissues, from model organisms and/or humans, in healthy and/or pathological scenarios. Thus far, dozens of methods have been proposed to quantify cell death-related parameters. However, no guidelines exist regarding their use and interpretation, and nobody has thoroughly annotated the experimental settings for which each of these techniques is most appropriate. Here, we provide a nonexhaustive comparison of …
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Scholar articles
L Galluzzi, SA Aaronson, J Abrams, ES Alnemri… - Cell Death & Differentiation, 2009