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ASIRPA is an original and comprehensive approach for assessing the socio-economic impact of public-sector research organizations through case studies. The cases are theory-based, selected to characterize the diversity of the broader impacts, and standardized so as to allow the scaling-up of the analysis of impact to the level of the organization. ASIRPA is founded on well-tried tools, and the added value of the approach lies in the adaptation and combination of these tools to design a comprehensive approach, which has been tested in a real situation and proven to be robust, credible, and implementable.