View article

Angioimmunoblastic T-cell lymphoma (AITL) is a rare, aggressive type of T-cell lymphoma (TCL) that accounts for 18.5% of mature T-cell or natural killer (NK)-cell lymphomas. 1 Mutations in the IDH2, TET2, and DNMT3A genes, frequently seen in various types of cancer, have also been linked to AITL. 2, 3 However, the molecular mechanisms governing AITL development are largely unknown. CD28 provides a co-stimulatory signal required for full T-cell activation. 4 Although many studies have demonstrated the importance of CD28 co-stimulation in T-cell function, the molecular mechanism underlying intracellular signal transduction triggered by CD28 ligation is poorly understood. We and other groups have previously reported identification of a somatic mutation of the CD28 gene, T195P, in AITL samples. 5, 6 Mutations in the CD28 gene have been rarely reported in other types of tumor and may play important …