Authors
Seok Jin Kim, Jae-Cheol Jo, Dok Hyun Yoon, Deok-Hwan Yang, Sang Eun Yoon, Gyeong-Won Lee, Jee Hyun Kong, Yong Park, Ka-Won Kang, Ho-Sup Lee, Sung Yong Oh, Ho-Jin Shin, Won Sik Lee, Yoon Seok Choi, Seong Hyun Jeong, Min Kyoung Kim, Hye Jin Kang, Jun Ho Yi, Sung-Nam Lim, Ho-Young Yhim, Young Rok Do, Hwan Jung Yun, Hyeon-Seok Eom, Mark Hong Lee, Cheolwon Suh, Won Seog Kim
Publication date
2023/8/22
Journal
Frontiers in Oncology
Volume
13
Pages
1230629
Publisher
Frontiers Media SA
Description
Introduction
Upfront autologous stem cell transplantation (ASCT) has been recommended for patients who are newly diagnosed with peripheral T-cell lymphoma (PTCL), and CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone), an anthracycline-based chemotherapy has been the frontline chemotherapy for PTCL. However, it is not clear whether anthracycline-based chemotherapies such as CHOP could be standard induction therapy for PTCL.
Methods
We conducted a randomized phase II study to compare CHOP with fractionated ifosfamide, carboplatin, etoposide, and dexamethasone (ICED) for patients eligible for ASCT. The primary endpoint was progression-free survival (PFS) and secondary endpoints included objective response rate, overall survival (OS), and safety profiles.
Results
Patients were randomized into either CHOP (n = 69) or ICED (n = 66), and the characteristics of both arms were not different. PTCL-not otherwise specified (NOS, n = 60) and angioimmunoblastic T-cell lymphoma (AITL, n = 53) were dominant. The objective response rate was not different between CHOP (59.4%) and ICED (56.1%), and the 3-year PFS was not different between CHOP (36.7%) and ICED (33.1%). In AITL patients, CHOP was favored over ICED whereas ICED was associated with more cytopenia and reduced dose intensity. Patients who received upfront ASCT after achieving complete response to CHOP or ICED showed 80% of 3-year OS.
Discussion
In summary, our study showed no therapeutic difference between CHOP and ICED in terms of response and PFS. Thus, CHOP might remain the reference regimen especially for …
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