Authors
Ken Ohmachi, Nozomi Niitsu, Toshiki Uchida, Seok Jin Kim, Kiyoshi Ando, Naoki Takahashi, Naoto Takahashi, Naokuni Uike, Hyeon Seok Eom, Yee Soo Chae, Takashi Terauchi, Ukihide Tateishi, Mitsuaki Tatsumi, Won Seog Kim, Kensei Tobinai, Cheolwon Suh, Michinori Ogura
Publication date
2013/6/10
Journal
Journal of clinical oncology
Volume
31
Issue
17
Pages
2103-2109
Publisher
American Society of Clinical Oncology
Description
Purpose
Effective and less aggressive therapies are required for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) who are not eligible for or have undergone autologous stem-cell transplantation (ASCT). The present phase II study assessed the efficacy and safety of bendamustine plus rituximab (BR) in this population.
Patients and Methods
Patients with relapsed or refractory DLBCL treated with one to three prior chemotherapy regimens received rituximab 375 mg/m2 intravenous (IV) infusion on day 1 and bendamustine 120 mg/m2 by IV infusion on days 2 and 3 of each 21-day cycle for up to six cycles. The primary end point was overall response rate (ORR), and the secondary end points were complete response (CR) rate, progression-free survival (PFS), and safety.
Results
Sixty-three patients were enrolled, and 59 received BR. The median age was 67 years (range, 36 to 75 years …
Scholar articles
K Ohmachi, N Niitsu, T Uchida, SJ Kim, K Ando… - Journal of clinical oncology, 2013