Authors
Li Wei, Yuting Gao, Katharina Theresa Prochazka, Rongqiu Liu, Liang Wang, Boyang Liu, Yingzhi He, Luca Bertero, Alessia Pellerino, Paola Cassoni, Luca Tamagnone, Alexander J Deutsch, Huien Zhan, Jing Lai, Seok Jin Kim, Hua You
Publication date
2023/6
Journal
Journal of Neuro-Oncology
Volume
163
Issue
2
Pages
301-311
Publisher
Springer US
Description
Background
Serum albumin has been demonstrated as prognostic parameter in non-Hodgkin lymphoma (NHL). Primary central nervous system lymphoma (PCNSL) is a rare extranodal NHL with highly aggressive behavior. In this study, we aimed at creating a novel prognostic model for PCNSL based on serum albumin levels.
Methods
We compared several commonly used laboratory nutritional parameters for predicting the survival of PCNSL patients using overall survival (OS) for outcome analysis and receiver operating characteristic curve analysis to determine the optimal cut-off values. Parameters associated with OS were evaluated by univariate and multivariate analyses. Independent prognostic parameters for OS were selected for risk stratification, including albumin ≤ 4.1 g/dL, ECOG PS > 1, and LLR > 166.8, which were associated with shorter OS; albumin > 4.1 g/dL, ECOG PS 0–1 and LLR ≤ …
Total citations
Scholar articles
L Wei, Y Gao, KT Prochazka, R Liu, L Wang, B Liu… - Journal of Neuro-Oncology, 2023