Authors
Eric Tse, Harinder Gill, Florence Loong, Seok Jin Kim, Siok‐Bian Ng, Tiffany Tang, Young‐Hyeh Ko, Wee‐Joo Chng, Soon‐Thye Lim, Won Seog Kim, Yok‐Lam Kwong
Publication date
2012/7
Journal
American journal of hematology
Volume
87
Issue
7
Pages
663-668
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Description
Enteropathy‐associated T‐cell lymphoma (EATL) is a rare primary gastrointestinal T‐cell lymphoma. A multicenter study from the Asia Lymphoma Study Group identified 38 EATL patients within a 19‐year period. All cases were type II EATL. Men were affected twice as common as women, at a median age of 59 (23–89) years. None had a history of celiac disease. The sites of involvement were small bowel and stomach (5%), small bowel (63%), small and large bowel (16%), and large bowel (18%). Common presenting features were bowel perforation (34%), pain (32%), and obstruction (21%). Lymphomas showed monomorphic neoplastic lymphoid infiltrates that were CD3+ (100%), CD56+ (91%), TIA‐1+ (96%), CD4CD8+ (63%), CD4+CD8+ (19%), CD4CD8 (16%), and CD4+CD8 (3%). Epstein Barr virus was demonstrable in three cases. Despite chemotherapy and/or surgical resection, the overall response …
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