Authors
Jia Nee Foo, Elaine Guo Yan Chew, Sun Ju Chung, Rong Peng, Cornelis Blauwendraat, Mike A Nalls, Kin Y Mok, Wataru Satake, Tatsushi Toda, Yinxia Chao, Louis CS Tan, Moses Tandiono, Michelle M Lian, Ebonne Y Ng, Kumar-M Prakash, Wing-Lok Au, Wee-Yang Meah, Shi Qi Mok, Azlina Ahmad Annuar, Anne YY Chan, Ling Chen, Yongping Chen, Beom S Jeon, Lulu Jiang, Jia Lun Lim, Juei-Jueng Lin, Chunfeng Liu, Chengjie Mao, Vincent Mok, Zhong Pei, Hui-Fang Shang, Chang-He Shi, Kyuyoung Song, Ai Huey Tan, Yih-Ru Wu, Yu-ming Xu, Renshi Xu, Yaping Yan, Jing Yang, BaoRong Zhang, Woon-Puay Koh, Shen-Yang Lim, Chiea Chuen Khor, Jianjun Liu, Eng-King Tan
Publication date
2020/6/1
Journal
JAMA neurology
Volume
77
Issue
6
Pages
746-754
Publisher
American Medical Association
Description
Importance
Large-scale genome-wide association studies in the European population have identified 90 risk variants associated with Parkinson disease (PD); however, there are limited studies in the largest population worldwide (ie, Asian).
Objectives
To identify novel genome-wide significant loci for PD in Asian individuals and to compare genetic risk between Asian and European cohorts.
Design Setting, and Participants
Genome-wide association data generated from PD cases and controls in an Asian population (ie, Singapore/Malaysia, Hong Kong, Taiwan, mainland China, and South Korea) were collected from January 1, 2016, to December 31, 2018, as part of an ongoing study. Results were combined with inverse variance meta-analysis, and replication of top loci in European and Japanese samples was performed. Discovery samples of 31 575 individuals passing quality control of 35 994 recruited were …
Scholar articles
JN Foo, EGY Chew, SJ Chung, R Peng… - JAMA neurology, 2020