Authors
Pierre-Antoine Juge, Joyce S Lee, Esther Ebstein, Hiroshi Furukawa, Evgenia Dobrinskikh, Steven Gazal, Caroline Kannengiesser, Sébastien Ottaviani, Shomi Oka, Shigeto Tohma, Naoyuki Tsuchiya, Jorge Rojas-Serrano, Montserrat I González-Pérez, Mayra Mejía, Ivette Buendía-Roldán, Ramcés Falfán-Valencia, Enrique Ambrocio-Ortiz, Effrosyni Manali, Spyros A Papiris, Theofanis Karageorgas, Dimitrios Boumpas, Katarina Antoniou, Coline HM van Moorsel, Joanne van der Vis, Yaël A de Man, Jan C Grutters, Yaping Wang, Raphaël Borie, Lidwine Wemeau-Stervinou, Benoît Wallaert, René-Marc Flipo, Hilario Nunes, Dominique Valeyre, Nathalie Saidenberg-Kermanac’h, Marie-Christophe Boissier, Sylvain Marchand-Adam, Aline Frazier, Pascal Richette, Yannick Allanore, Jean Sibilia, Claire Dromer, Christophe Richez, Thierry Schaeverbeke, Huguette Lioté, Gabriel Thabut, Nadia Nathan, Serge Amselem, Martin Soubrier, Vincent Cottin, Annick Clément, Kevin Deane, Avram D Walts, Tasha Fingerlin, Aryeh Fischer, Jay H Ryu, Eric L Matteson, Timothy B Niewold, Deborah Assayag, Andrew Gross, Paul Wolters, Marvin I Schwarz, Michael Holers, Joshua J Solomon, Tracy Doyle, Ivan O Rosas, Cornelis Blauwendraat, Mike A Nalls, Marie-Pierre Debray, Catherine Boileau, Bruno Crestani, David A Schwartz, Philippe Dieudé
Publication date
2018/12/6
Journal
New England Journal of Medicine
Volume
379
Issue
23
Pages
2209-2219
Publisher
Massachusetts Medical Society
Description
Background
Given the phenotypic similarities between rheumatoid arthritis (RA)–associated interstitial lung disease (ILD) (hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we hypothesized that the strongest risk factor for the development of idiopathic pulmonary fibrosis, the gain-of-function MUC5B promoter variant rs35705950, would also contribute to the risk of ILD among patients with RA.
Methods
Using a discovery population and multiple validation populations, we tested the association of the MUC5B promoter variant rs35705950 in 620 patients with RA-ILD, 614 patients with RA without ILD, and 5448 unaffected controls.
Results
Analysis of the discovery population revealed an association of the minor allele of the MUC5B promoter variant with RA-ILD when patients with RA-ILD were compared with unaffected controls (adjusted odds ratio, 3.8; 95% confidence interval [CI], 2.8 to 5.2; P=9.7×10−17). The …
Scholar articles
PA Juge, JS Lee, E Ebstein, H Furukawa… - New England Journal of Medicine, 2018