Authors
Hirotaka Iwaki, Cornelis Blauwendraat, Hampton L Leonard, Ganqiang Liu, Jodi Maple-Grødem, Jean-Christophe Corvol, Lasse Pihlstrøm, Marlies Van Nimwegen, Samantha J Hutten, Khanh-Dung H Nguyen, Jacqueline Rick, Shirley Eberly, Faraz Faghri, Peggy Auinger, Kirsten M Scott, Ruwani Wijeyekoon, Vivianna M Van Deerlin, Dena G Hernandez, Aaron G Day-Williams, Alexis Brice, Guido Alves, Alastair J Noyce, Ole-Bjørn Tysnes, Jonathan R Evans, David P Breen, Karol Estrada, Claire E Wegel, Fabrice Danjou, David K Simon, Bernard Ravina, Mathias Toft, Peter Heutink, Bastiaan R Bloem, Daniel Weintraub, Roger A Barker, Caroline H Williams-Gray, Bart P Van De Warrenburg, Jacobus J Van Hilten, Clemens R Scherzer, Andrew B Singleton, Mike A Nalls
Publication date
2019/7/9
Journal
Neurology: Genetics
Volume
5
Issue
4
Pages
e348
Publisher
Wolters Kluwer
Description
Objective
To determine if any association between previously identified alleles that confer risk for Parkinson disease and variables measuring disease progression.
Methods
We evaluated the association between 31 risk variants and variables measuring disease progression. A total of 23,423 visits by 4,307 patients of European ancestry from 13 longitudinal cohorts in Europe, North America, and Australia were analyzed.
Results
We confirmed the importance of GBA on phenotypes. GBA variants were associated with the development of daytime sleepiness (p.N370S: hazard ratio [HR] 3.28 [1.69–6.34]) and possible REM sleep behavior (p.T408M: odds ratio 6.48 [2.04–20.60]). We also replicated previously reported associations of GBA variants with motor/cognitive declines. The other genotype-phenotype associations include an intergenic variant near LRRK2 and the faster development of motor symptom (Hoehn and …
Scholar articles
H Iwaki, C Blauwendraat, HL Leonard, G Liu… - Neurology: Genetics, 2019