Authors
Hirotaka Iwaki, Cornelis Blauwendraat, Hampton L Leonard, Jonggeol J Kim, Ganqiang Liu, Jodi Maple‐Grødem, Jean‐Christophe Corvol, Lasse Pihlstrøm, Marlies van Nimwegen, Samantha J Hutten, Khanh‐Dung H Nguyen, Jacqueline Rick, Shirley Eberly, Faraz Faghri, Peggy Auinger, Kirsten M Scott, Ruwani Wijeyekoon, Vivianna M Van Deerlin, Dena G Hernandez, J Raphael Gibbs, International Parkinson's Disease Genomics Consortium, Kumaraswamy Naidu Chitrala, Aaron G Day‐Williams, Alexis Brice, Guido Alves, Alastair J Noyce, Ole‐Bjørn Tysnes, Jonathan R Evans, David P Breen, Karol Estrada, Claire E Wegel, Fabrice Danjou, David K Simon, Ole Andreassen, Bernard Ravina, Mathias Toft, Peter Heutink, Bastiaan R Bloem, Daniel Weintraub, Roger A Barker, Caroline H Williams‐Gray, Bart P van de Warrenburg, Jacobus J Van Hilten, Clemens R Scherzer, Andrew B Singleton, Mike A Nalls
Publication date
2019/12
Journal
Movement Disorders
Volume
34
Issue
12
Pages
1839-1850
Publisher
John Wiley & Sons, Inc.
Description
Background
Several reports have identified different patterns of Parkinson's disease progression in individuals carrying missense variants in GBA or LRRK2 genes. The overall contribution of genetic factors to the severity and progression of Parkinson's disease, however, has not been well studied.
Objectives
To test the association between genetic variants and the clinical features of Parkinson's disease on a genomewide scale.
Methods
We accumulated individual data from 12 longitudinal cohorts in a total of 4093 patients with 22,307 observations for a median of 3.81 years. Genomewide associations were evaluated for 25 cross‐sectional and longitudinal phenotypes. Specific variants of interest, including 90 recently identified disease‐risk variants, were also investigated post hoc for candidate associations with these phenotypes.
Results
Two variants were genomewide significant. Rs382940(T>A), within …
Scholar articles
H Iwaki, C Blauwendraat, HL Leonard, JJ Kim, G Liu… - Movement Disorders, 2019