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In the present study, the roles of renal tubular γ-glutamyl transpeptidase and renal organic anion transport on the renal uptake and accumulation and intrarenal distribution of injected inorganic mercury were investigated. The renal (and general) disposition of injected inorganic mercury (Hg²⁺) was evaluated in control rats, rats pretreated with two 10 mg/kg doses of acivicin, rats pretreated with a 10 mmol/kg dose of p-aminohippurate (PAH), and rats pretreated with both acivicin and PAH. The dose(s) of acivicin were used to inhibit the activity of renal γ-glutamyl transpeptidase to a near maximal level and the dose of PAH (which is a water-soluble organic anion) was used to competitively inhibit the renal organic anion transport system to a near maximal level. Dispositional data were obtained at both 1 and 24 hr after a nontoxic, 0.5 μmol/kg iv dose of mercuric chloride had been administered. Radiolabeled inorganic …