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To compare the 1‐year clinical and microbiological outcomes of an enhanced anti‐infective therapy with versus without systemic antimicrobials in patients with generalized aggressive periodontitis (GAP).

In this 12‐month randomized, double‐blinded, placebo‐controlled trial, 35 individuals assigned to a control (n = 17) or test group (n = 18) received full‐mouth supra and subgingival ultrasonic debridement followed by scaling and root planing with chlorhexidine rinsing, brushing, and irrigation. Subjects received either amoxicillin (AMX, 500 mg) + metronidazole (MET, 250 mg) or placebos, TID for 10 days. Subgingival samples were obtained and analysed for their composition by checkerboard. Data were subjected to non‐parametric tests.

Both therapeutic protocols resulted in similar significant clinical improvement for most parameters at 1 year (p < 0.01). The AMX + MET group exhibited …