Authors
Isadora FG Sena, Beatriz GS Rocha, Caroline C Picoli, Gabryella SP Santos, Alinne C Costa, Bryan OP Gonçalves, Ana Paula V Garcia, Maryam Soltani-Asl, Leda MC Coimbra-Campos, Walison N Silva, Pedro AC Costa, Mauro CX Pinto, Jaime H Amorim, Vasco AC Azevedo, Rodrigo R Resende, Debora Heller, Geovanni D Cassali, Akiva Mintz, Alexander Birbrair
Publication date
2021/8
Journal
Histochemistry and Cell Biology
Volume
156
Issue
2
Pages
165-182
Publisher
Springer Berlin Heidelberg
Description
Diagnosis and prognosis of breast cancer is based on disease staging identified through histopathological and molecular biology techniques. Animal models are used to gain mechanistic insights into the development of breast cancer. C(3)1-TAg is a genetically engineered mouse model that develops mammary cancer. However, carcinogenesis caused by this transgene was characterized in the Friend Virus B (FVB) background. As most genetic studies are done in mice with C57BL/6 J background, we aimed to define the histological alterations in C3(1)-TAg C57BL/6 J animals. Our results showed that C3(1)-TAg animals with C57BL/6 J background develop solid-basaloid adenoid cystic carcinomas with increased fibrosis, decreased area of adipocytes, and a high proliferative index, which are triple-negative for progesterone, estrogen, and human epidermal growth factor receptor 2 (HER2) receptors. Our results …
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Scholar articles
IFG Sena, BGS Rocha, CC Picoli, GSP Santos… - Histochemistry and Cell Biology, 2021