View article

In the present study, extraction of mebendazole across a supported-liquid membrane (SLM) was performed based on two different driving forces: (1) pH gradient over the SLM, and (2) electrical field sustained over the SLM. The extracted drug concentration was studied using reversed-phase HPLC–UV. At passive extraction conditions, mebendazole was extracted from alkaline samples (0.01mmolL⁻¹ NaOH) into 1-undecanol immobilized in the pores of a porous hollow fiber of polypropylene (SLM), and then transported into 25μL of 100mM HCl as the acceptor solution. Under electrokinetic migration conditions, mebendazole transported under applied voltage from acidic solutions (100mmolL⁻¹ HCl) through 2-nitrophenyl octyl ether (NPOE) immobilized in the pores of hollow fiber, into 25μL of 100mmolL⁻¹ HCl as the acceptor solution. The effects of several factors including the nature of organic solvent, pH of donor …