Authors
Taiji Kawakatsu, Shao-shan Carol Huang, Florian Jupe, Eriko Sasaki, Robert J Schmitz, Mark A Urich, Rosa Castanon, Joseph R Nery, Cesar Barragan, Yupeng He, Huaming Chen, Manu Dubin, Cheng-Ruei Lee, Congmao Wang, Felix Bemm, Claude Becker, Ryan O’Neil, Ronan C O’Malley, Danjuma X Quarless, Carlos Alonso-Blanco, Jorge Andrade, Joy Bergelson, Karsten Borgwardt, Eunyoung Chae, Todd Dezwaan, Wei Ding, Joseph R Ecker, Moisés Expósito-Alonso, Ashley Farlow, Joffrey Fitz, Xiangchao Gan, Dominik G Grimm, Angela Hancock, Stefan R Henz, Svante Holm, Matthew Horton, Mike Jarsulic, Randall A Kerstetter, Arthur Korte, Pamela Korte, Christa Lanz, Chen-Ruei Lee, Dazhe Meng, Todd P Michael, Richard Mott, Ni Wayan Muliyati, Thomas Nägele, Matthias Nagler, Viktoria Nizhynska, Magnus Nordborg, Polina Novikova, F Xavier Picó, Alexander Platzer, Fernando A Rabanal, Alex Rodriguez, Beth A Rowan, Patrice A Salomé, Karl Schmid, Ümit Seren, Felice Gianluca Sperone, Mitchell Sudkamp, Hannes Svardal, Matt M Tanzer, Donald Todd, Samuel L Volchenboum, George Wang, Xi Wang, Wolfram Weckwerth, Detlef Weigel, Xuefeng Zhou, Nicholas J Schork
Publication date
2016/7/14
Journal
Cell
Volume
166
Issue
2
Pages
492-505
Publisher
Elsevier
Description
The epigenome orchestrates genome accessibility, functionality, and three-dimensional structure. Because epigenetic variation can impact transcription and thus phenotypes, it may contribute to adaptation. Here, we report 1,107 high-quality single-base resolution methylomes and 1,203 transcriptomes from the 1001 Genomes collection of Arabidopsis thaliana. Although the genetic basis of methylation variation is highly complex, geographic origin is a major predictor of genome-wide DNA methylation levels and of altered gene expression caused by epialleles. Comparison to cistrome and epicistrome datasets identifies associations between transcription factor binding sites, methylation, nucleotide variation, and co-expression modules. Physical maps for nine of the most diverse genomes reveal how transposons and other structural variants shape the epigenome, with dramatic effects on immunity genes. The 1001 …
Scholar articles
T Kawakatsu, SC Huang, F Jupe, E Sasaki, RJ Schmitz… - Cell, 2016