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Laser surface texturing (LST) processes have great potential to alter surface wetting properties of widely known bioactive Ti–6Al–4V alloy. Micro-pillars arrays of different topography are produced by Nd:YAG laser of 1064 nm wavelength to investigate the influence of its physical and geometrical parameter on wettability. Micro-textures named as: T_HS (high density, square pillars of 30 × 30 μm), T_MS (medium density, square pillars of 60 × 60 μm), T_LS (low density, square pillars of 170 × 170 μm), T_LL (low density, landscape pillars of 300 × 100 μm) and T_LP (low density, portrait pillars of 100 × 300 μm) are produced to analyze the effect of texture areal density, aspect ratio and shape over surface wetting phenomenon. It is observed that on the flat textured surface shows hydrophilic and spontaneous wetting behavior up to 24 h after machining. Percentage increment in water contact angle (CA …