Authors
Muhammad Hammadah, Ayman Alkhoder, Ibhar Al Mheid, Kobina Wilmot, Nino Isakadze, Naser Abdulhadi, Danielle Chou, Malik Obideen, Wesley T O'Neal, Samaah Sullivan, Ayman Samman Tahhan, Heval Mohamed Kelli, Ronnie Ramadan, Pratik Pimple, Pratik Sandesara, Amit J Shah, Laura Ward, Yi-An Ko, Yan Sun, Irina Uphoff, Brad Pearce, Ernest V Garcia, Michael Kutner, J Douglas Bremner, Fabio Esteves, David S Sheps, Paolo Raggi, Viola Vaccarino, Arshed A Quyyumi
Publication date
2017/9/15
Journal
International journal of cardiology
Volume
243
Pages
47-53
Publisher
Elsevier
Description
Aims
Mental stress-induced myocardial ischemia (MSIMI) in patients with coronary artery disease (CAD) is associated with adverse cardiovascular outcomes. We aim to assess hemodynamic, neuro-hormonal, endothelial, vasomotor and vascular predictors of MSIMI.
Methods and results
We subjected 660 patients with stable CAD to 99mTc sestamibi myocardial perfusion imaging at rest, with mental (speech task) and with conventional (exercise/pharmacological) stress. Endothelium-dependent flow-mediated dilation (FMD), microvascular reactivity [reactive hyperemia index (RHI)] and arterial stiffness [pulse wave velocity (PWV)] were measured at rest and 30-min after mental stress. The digital microvascular vasomotor response during mental stress was assessed using peripheral arterial tonometry (PAT). A total of 106(16.1%) patients had MSIMI. Mental stress was accompanied by significant increases in rate …
Scholar articles
M Hammadah, A Alkhoder, I Al Mheid, K Wilmot… - International journal of cardiology, 2017