Authors
Rebecca L Ross, Kim D Jones, Robert M Bennett, Rachel L Ward, Brian J Druker, Lisa J Wood
Publication date
2010
Journal
The open immunology journal
Volume
3
Pages
9
Publisher
NIH Public Access
Description
Mounting evidence suggests fibromyalgia (FM) symptoms are influenced by dysfunction of the hypothalamic-pituitary-hormonal axes (HPHA) and the immune response system. The predominant FM symptoms of widespread pain, fatigue, sleep disturbance, depression, stiffness and exercise intolerance are related to abnormal levels of growth hormone (GH) and are reminiscent of “sickness behavior”; a syndrome initiated by the production of pro-inflammatory cytokines in response to various stressors. Cognizant of the reciprocal relationship between HPHA activity and the immune response system, we hypothesized that serum cytokine levels and FM symptom severity would be higher in FM patients with defective growth hormone response to exhaustive exercise compared to those without. Outpatients with FM (n= 165) underwent a Modified Balke Treadmill Protocol and GH response to exhaustive exercise was …
Scholar articles
RL Ross, KD Jones, RM Bennett, RL Ward, BJ Druker… - The open immunology journal, 2010