Authors
Yi Xu, Takita Felder Sumter, Raka Bhattacharya, Abeba Tesfaye, Ephraim J Fuchs, Lisa J Wood, David L Huso, Linda MS Resar
Publication date
2004/5/15
Journal
Cancer Research
Volume
64
Issue
10
Pages
3371-3375
Publisher
American Association for Cancer Research
Description
HMG-I/Y is overexpressed in human cancer, although a direct role for this gene in transformation has not been established. We generated transgenic mice with HMG-I targeted to lymphoid cells. All seven informative founder HMG-I mice developed aggressive lymphoma by a mean age of 4.8 months. Tumors express T-cell markers and are transplantable. We also demonstrate that HMG-I mRNA and protein are increased in human acute lymphocytic leukemia samples. Our results show that HMG-I functions as an oncogene and suggest that it contributes to the pathogenesis of leukemia and other cancers with increased HMG-I expression.
Total citations
Scholar articles
Y Xu, TF Sumter, R Bhattacharya, A Tesfaye, EJ Fuchs… - Cancer Research, 2004