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Social aspects of collegiate holiday drinking have been studied frequently, but physiological consequences are often overlooked. This study examined self-reported stress, endocrine and immune indicators in students at an American university before and after their week-long spring break (SB) holiday. Participants (n= 27; 9 males) provided saliva samples and completed surveys pre-and post-SB. Based on their cortisol reaction to SB, participants were grouped as cortisol nonresponders (CNR; n= 14) or increasers (CI; n= 13). Groups were matched on demographics, baseline alcohol use, family history of alcoholism, and SB plans. Differences over time and between groups were examined for α-amylase, quantity/frequency of alcohol use (quantity/frequency index, QFI) and the immunoglobulin A (IgA) to albumin ratio (IgA: albumin). α-Amylase decreased over time. A time× group …