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Increasing mortality rate and case of occurrence makes cancer a huge public health challenge in both developed and developing countries [1]. Toxicity, adverse effects, and non-specificity are some of the major problems with the current drugs used in cancer chemotherapy [2]. For centuries, mushrooms have been used for their medicinal properties by different cultures [3]. In the past few decades, several natural bioactive compounds from mushrooms have been reported to exhibit anti-cancer properties by means of anti-proliferation (reduced cell viability), immuno-stimulation (stimulating production of cytokines), apoptosis (programmed cell death) and anti-inflammation (inhibiting excess unregulated cytokine production)[3].

This study aims to investigate potential anti-cancer properties of a wood-decaying wild mushroom, Trichaptum abietinum (Ryvarden L., 1972)[Polyporaceae], which is native to British Columbia …