Authors
Michael D Hill, Mayank Goyal, Bijoy K Menon, Raul G Nogueira, Ryan A McTaggart, Andrew M Demchuk, Alexandre Y Poppe, Brian H Buck, Thalia S Field, Dar Dowlatshahi, Brian A van Adel, Richard H Swartz, Ruchir A Shah, Eric Sauvageau, Charlotte Zerna, Johanna M Ospel, Manish Joshi, Mohammed A Almekhlafi, Karla J Ryckborst, Mark W Lowerison, Kathy Heard, David Garman, Diogo Haussen, Shawna M Cutting, Shelagh B Coutts, Daniel Roy, Jeremy L Rempel, Axel CR Rohr, Daniela Iancu, Demetrios J Sahlas, YX Amy, Thomas G Devlin, Ricardo A Hanel, Volker Puetz, Frank L Silver, Bruce CV Campbell, René Chapot, Jeanne Teitelbaum, Jennifer L Mandzia, Timothy J Kleinig, David Turkel-Parrella, Donald Heck, Michael E Kelly, Aditya Bharatha, Oh Young Bang, Ashutosh Jadhav, Rishi Gupta, Donald F Frei, Jason W Tarpley, Cameron G McDougall, Staffan Holmin, Joung-Ho Rha, Ajit S Puri, Marie-Christine Camden, Götz Thomalla, Hana Choe, Stephen J Phillips, Joseph L Schindler, John Thornton, Simon Nagel, Ji Hoe Heo, Sung-Il Sohn, Marios-Nikos Psychogios, Ronald F Budzik, Sidney Starkman, Coleman O Martin, Paul A Burns, Seán Murphy, George A Lopez, Joey English, Michael Tymianski, Andrew Demchuk, Philip Barber, Eric Smith, Simerpreet Bal, Suresh Subramaniam, Steven Peters, Phillippe Couillard, Gary Klein, Peter Stys, Bijoy Menon, Shelagh Coutts, Mohammed Almekhlafi, Michael Hill, John Wong, Alim Mitha, Muneer Eesa, William Morrish, Saad Alqatani, Nima Kashani, Johanna Ospel, Prasanna Venkatesan, Erika Teleg, Amith Sitaram, Brett Graham, Stephen Van Gaal, Aimen Moussaddy, Debabrata Chakraborty, Nicholas Maraj, Andrew Loockey, Shuo Chen, Ravinder Singh, Abdulaziz Alsultan, Ria Asuncion, Dominic Tse, Darshan Doshi, Ondrej Volny, Piyush Ojha, Ankur Wadhwa, Martha Marko, Nishita Singh, Sanchea Wasyliw, Karla Ryckborst, Carol Kenney, Supriya Save, Anitha Jambula, Nancy Newcommon, Gavin Hull, Darcy Blackstock, Sharon Kiszczak, Leslie Zimmel, Michelle Wright, Cari Jahraus, Linda Andersen, Shelly Bohn, Joseph Paul, Oiao Zhang, Craig Doram, Mark Lowerison, Andrea Hanley, Lori Campbell, Ashley Ure, Francis Taylor, Dominic Hul, Samuel Wiebe, Marina Saluzzi, Nicole Blenkin, Richard Frayne, Brian Buck, Kenneth Butcher, Ashfaq Shuaib, Tom Jeerakathil, Glen Jickling, Derek Emery, Jeremy Rempel, Richard Owen, Robert Ashforth, Tom Yeo, Trevor Kotylak, Cian O'Kelly
Publication date
2020/3/14
Journal
The Lancet
Volume
395
Issue
10227
Pages
878-887
Publisher
Elsevier
Description
Background
Nerinetide, an eicosapeptide that interferes with post-synaptic density protein 95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia-reperfusion. In this trial, we assessed the efficacy and safety of nerinetide in human ischaemia-reperfusion that occurs with rapid endovascular thrombectomy in patients who had an acute ischaemic stroke.
Methods
For this multicentre, double-blind, randomised, placebo-controlled study done in 48 acute care hospitals in eight countries, we enrolled patients with acute ischaemic stroke due to large vessel occlusion within a 12 h treatment window. Eligible patients were aged 18 years or older with a disabling ischaemic stroke at the time of randomisation, had been functioning independently in the community before the stroke, had an Alberta Stroke Program Early CT Score (ASPECTS) greater than 4, and vascular imaging showing moderate-to …
Scholar articles
MD Hill, M Goyal, BK Menon, RG Nogueira… - The Lancet, 2020