Authors
Kazuya Yamagata, Naohisa Oda, Pamela J Kaisaki, Stephan Menzel, Hiroto Furuta, Martine Vaxillaire, Lorraine Southam, Roger D Cox, G Mark Lathrop, V Vicky Boriraj, Xiangna Chen, Nancy J Cox, Yukie Oda, Hideki Yano, Michelle M Le Beau, Shirou Yamada, Hidekazu Nishigori, Jun Takeda, Stefan S Fajans, Andrew T Hattersley, Naoko Iwasaki, Torben Hansen, Oluf Pedersen, Kenneth S Polonsky, Robert C Turner, Gilberto Velho, Jean-Claude Chèvre, Philippe Froguel, Graeme I Bell
Publication date
1996/12/5
Journal
Nature
Volume
384
Issue
6608
Pages
455-458
Publisher
Nature Publishing Group UK
Description
THE disease non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is characterized by abnormally high blood glucose resulting from a relative deficiency of insulin1. It affects about 2% of the world's population and treatment of diabetes and its complications are an increasing health-care burden2. Genetic factors are important in the aetiology of NIDDM, and linkage studies are starting to localize some of the genes that influence the development of this disorder3. Maturity-onset diabetes of the young (MODY), a single-gene disorder responsible for 2–5% of NIDDM, is characterized by autosomal dominant inheritance and an age of onset of 25 years or younger4–6. MODY genes have been localized to chromosomes 7, 12 and 20 (refs 5, 7, 8) and clinical studies indicate that mutations in these genes are associated with abnormal patterns of glucose-stimulated insulin secretion1,9. The gene on chromosome 7 …
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Scholar articles
K Yamagata, N Oda, PJ Kaisaki, S Menzel, H Furuta… - Nature, 1996