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Background: Recent change in mammography reporting guidelines by US FDA highlights the need for an additional supplemental screening modality for women with dense breasts. Furthermore, American College of Radiology updated its screening guidelines recommending annual screening beginning at age 40 for women of average risk and even earlier for women at higherthan-average risk. Even European Guidelines suggest not implementing mammography screening for asymptomatic average-risk women aged 40 to 44 due to breast density issues. A supplemental screening with Breast MRI is not affordable for many countries.

In this paper, we evaluate the efficacy of Thermalytix, a low-cost artificial intelligence-based screening test for its potential to be a supplemental screening modality for women younger than 45 years. Thermalytix involves computer-aided analysis of high resolution thermal scans using …