Authors
Ariane Galaup, Elisa Gomez, Rachid Souktani, Mélanie Durand, Aurélie Cazes, Catherine Monnot, Jérémie Teillon, Sébastien Le Jan, Claire Bouleti, Gaëlle Briois, Josette Philippe, Sandrine Pons, Valérie Martin, Rana Assaly, Philippe Bonnin, Philippe Ratajczak, Anne Janin, Gavin Thurston, David M Valenzuela, Andrew J Murphy, George D Yancopoulos, Renaud Tissier, Alain Berdeaux, Bijan Ghaleh, Stéphane Germain
Publication date
2012/1/3
Journal
Circulation
Volume
125
Issue
1
Pages
140-149
Publisher
Lippincott Williams & Wilkins
Description
Background
Increased permeability, predominantly controlled by endothelial junction stability, is an early event in the deterioration of vascular integrity in ischemic disorders. Hemorrhage, edema, and inflammation are the main features of reperfusion injuries, as observed in acute myocardial infarction (AMI). Thus, preservation of vascular integrity is fundamental in ischemic heart disease. Angiopoietins are pivotal modulators of cell–cell junctions and vascular integrity. We hypothesized that hypoxic induction of angiopoietin-like protein 4 (ANGPTL4) might modulate vascular damage, infarct size, and no-reflow during AMI.
Methods and Results
We showed that vascular permeability, hemorrhage, edema, inflammation, and infarct severity were increased in angptl4-deficient mice. We determined that decrease in vascular endothelial growth factor receptor 2 (VEGFR2) and VE-cadherin expression and increase in Src …
Total citations
Scholar articles
A Galaup, E Gomez, R Souktani, M Durand, A Cazes… - Circulation, 2012