Authors
Loai Althagafi, Melanie Davies, Kelly Parke, Emer Brady, Zin Htike, Daniel Swabrick, Lavanya Athithan, Tom Yates, Gaurav Gulsin, Gerry McCann, Joanne Wormleighton, Thomas Webb
Publication date
2023/6/1
Source
Heart
Volume
109
Issue
Suppl 3
Pages
A170-A171
Publisher
BMJ Publishing Group Ltd and British Cardiovascular Society
Description
Background
People with Type 2 Diabetes (T2D) and obesity have ectopic fat deposition and are at increased risk of heart failure with preserved Ejection Fraction (HFpEF). HFpEF is typified by impaired diastolic function. There is limited evidence on the relationship between visceral adipose tissue (VAT) and diastolic or systolic function in adults with T2D. The aim of this work was to determine if: 1) there is an independent relationship between VAT and diastolic or systolic function in a multi-ethnic cohort of obese people with T2D and 2) if a reduction in VAT following lifestyle or pharmacotherapy is associated with improved diastolic or systolic function.
Methods
This secondary analysis includes pooled data from two randomised controlled trials (LYDIA (NCT02043054) and the DIASTOLIC study (NCT02590822)). Participants were obese with T2D and no history or symptoms of cardiovascular disease. Multiparametric …
Scholar articles
L Althagafi, M Davies, K Parke, E Brady, Z Htike… - 2023