Authors
Emma G Wilmot, Charlotte L Edwardson, Felix A Achana, Melanie J Davies, Trish Gorely, Laura J Gray, Kamlesh Khunti, Thomas Yates, Stuart JH Biddle
Publication date
2012/11
Source
Diabetologia
Volume
55
Issue
11
Pages
2895-2905
Publisher
Springer-Verlag
Description
Methods
Medline, Embase and the Cochrane Library databases were searched for terms related to sedentary time and health outcomes. Cross-sectional and prospective studies were included. RR/HR and 95% CIs were extracted by two independent reviewers. Data were adjusted for baseline event rate and pooled using a random-effects model. Bayesian predictive effects and intervals were calculated to indicate the variance in outcomes that would be expected if new studies were conducted in the future.
Results
Eighteen studies (16 prospective, two cross-sectional) were included, with 794,577 participants. Fifteen of these studies were moderate to high quality. The greatest sedentary time compared with the lowest was associated with a 112% increase in the RR of diabetes (RR 2.12; 95% credible interval [CrI] 1.61, 2.78), a 147% increase in the RR of cardiovascular events (RR 2.47; 95% CI 1.44, 4.24), a 90 …
Total citations
Scholar articles
EG Wilmot, CL Edwardson, FA Achana, MJ Davies… - Diabetologia, 2012