Authors
Sidse M Arnfred, Andrew CN Chen, Birte Y Glenthøj, Ralf P Hemmingsen
Publication date
2003/12/1
Journal
American Journal of Psychiatry
Volume
160
Issue
12
Pages
2236-2238
Publisher
American Psychiatric Publishing
Description
OBJECTIVE
The hypothesis of a sensory gating defect in schizophrenia has been supported by studies demonstrating deficient auditory P50 gating in patients. P50 gating is the relative attenuation of P50 amplitude in the auditory evoked potential following the second auditory stimulus of a stimulus pair.
METHOD
Auditory evoked potentials of 12 unmedicated male patients with schizophrenia and 24 healthy men were recorded during three runs of 40 click pairs. Three alternative waveform-processing strategies were used to analyze the data.
RESULTS
Regardless of strategy used, the differences between subject groups regarding P50 amplitude and gating were nonsignificant.
CONCLUSIONS
The P50 gating in the patient group was normal. The results do not support the concept of the P50 gating defect as a general trait marker of schizophrenia.
Total citations
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Scholar articles
SM Arnfred, ACN Chen, BY Glenthøj, RP Hemmingsen - American Journal of Psychiatry, 2003